Collagenase immunolocalization studies of cutaneous secondary melanomas
نویسندگان
چکیده
منابع مشابه
Apoptosis in cutaneous melanomas.
Cutaneous melanomas has become one of the most discussed and studied tumor because its particular immunologic development but also its increasing rate worldwide in the last decades. Even thought many patients are diagnosed at an early stage, the death rate continues to rise due to the increasing incidence of more advanced lesions. The aim of this study is to detect apoptosis in 30 cases of cuta...
متن کاملClinical appearance of cutaneous melanomas.
Brown and black spots are present on the skin of all people. Melanomas compromise only a very small percentage of all such pigmented lesions but are responsible for most of the deaths and illness caused by pigment cells. Three types of melanomas can be distinguished from their clinical, histologic, and biologic characteristics: lentigo maligna, superficial spreading melanoma, and nodular melano...
متن کاملCutaneous melanomas associated with nevi.
OBJECTIVE To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus. DESIGN Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed. SETTING Independent, community-based dermatopathology laboratory. PATIENTS A total of 1606 patients with a histol...
متن کاملBiochemical and immunolocalization studies
1. A liver canalicular plasma-membrane fraction enriched 115-155-fold in five marker enzymes relative to the tissue homogenate was obtained by sonication of liver plasma membranes followed by fractionation in iso-osmotic Nycodenz gradients. 2. Two lateral-plasma membrane fractions were also collected by this procedure; the lighter-density fraction was still associated with canalicular membranes...
متن کاملMolecular Bases of Cutaneous and Uveal Melanomas
Intensive research in recent years has begun to unlock the mysteries surrounding the molecular pathogenesis of melanoma, the deadliest of skin cancers. The high-penetrance, low-frequency susceptibility gene CDKN2A produces tumor suppressor proteins that function in concert with p53 and retinoblastoma protein to thwart melanomagenesis. Aberrant CDKN2A gene products have been implicated in a grea...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1980
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1980.225